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Premature ejaculation (PE) is a condition in which a man ejaculates earlier than he or his partner would like him to. Premature ejaculation is also known as rapid ejaculation, rapid climax, premature climax, or early ejaculation. 
Most men experience premature ejaculation at least once in their lives. Because there is great variability in both how long it takes men to ejaculate and how long both partners want sex to last, if at all, an accurate prevalence rate is hard to determine, estimates range from as low as 5% to as high as 30% Nevertheless, it is possible that men with abnormally low IELTs could be “happy” with their performance and do not report a lack of control. Likewise men with higher IELTs may consider themselves premature ejaculators, suffer from detrimental side effects normally associated with premature ejaculation, and even benefit from treatment.
 Possible physical factors
 Mechanism of ejaculation
The physical process of ejaculation requires two actions: emission and expulsion.
The emission is the first phase. It involves deposition fluid from the 
It is believed that the selective serotonin reuptake inhibitors (SSRIs), which increase serotonin level in the synapse, in treating Premature Ejaculation.
Sympathetic motor neurons control the emission phase of 
Several areas in the brain, and especially the nucleus paragigantocellularis, have been identified to be involved in ejaculatory control. Some men prefer using anaesthetic creams; however, these creams may also deaden sensations in the man’s partner, and are not generally recommended by sex therapists.
 Differential diagnosis
Premature ejaculation should be distinguished from erectile dysfunction related to the development of a general medical condition, and a diagnosis should be made using the patient’s sexual history looking for a history of; decreased sexual arousal may be so high that ejaculation occurs immediately. Occasional problems with premature ejaculation that are not persistent or recurrent or are not accompanied by marked distress or interpersonal difficulty do not qualify for the diagnosis of premature ejaculation. The clinician should also take into account the individual’s age, overall sexual experience, recent sexual activity, and the novelty of the partner. When problems with premature ejaculation are due exclusively to substance use (e.g., opioid withdrawal), a substance-induced sexual dysfunction can be diagnosed.
 Other ejaculation disorder types
- Delayed ejaculation – Ejaculation takes a long time
- Retrograde ejaculation – Semen flows from the prostate gland into the bladder rather than exiting out of the penis.
- Inhibited orgasm in males
When deciding the appropriate treatment, it is important for physician to distinguish PE as a “complaint” versus PE as a “syndrome”.
Clomipramine (Anafranil) is sometimes prescribed to treat PE. One side effect of the drug can help delay ejaculatory response. The side effect is described by the Mayo Clinic as “Increased [sic] sexual ability, desire, drive, or performance.”
Desensitizing creams that are applied to the tip and shaft of the penis can also be used prevent premature ejaculation. Such creams are applied on an “as needed” basis and have fewer systemic side effects. However, use of these creams may lead to insensitivity in the penis, and reduction of sensation for the partner due to contamination.
One more method is entitled intracavernous pharmacotherapy. This is a method of injecting a drug known as a vasodilator directly into the penis to help men control premature ejaculation and maintain their erection. It has been proven to be effective in over seventy percent of test patients. This method is used by companies such as Florida Men’s Medical Clinic, Boston Medical Group and others.
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- PRILIGY (Dapoxetin) erhält die Zulassung für die Behandlung der Ejaculatio praecox in Deutschland
- Janssen-Cilag EMEA announces receipt of first regulatory approvals for Priligy for PE in Finland and Sweden, February 11, 2009
- Herrera (2011-10-28). “Scientific Studies/Articles: Premature Ejaculation and Successful Tramadol Treatment”. http://www.tramadol4pe.com/scientific-studies.html. Retrieved 2011-11-15.
- Kaynar, M. & Abdel-Hamid, I.A. On-Demand Tramadol Hypochloride Use in Premature Ejaculation Treatment. Journal of Urology 2012; 71(31):145-149
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- Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal cord injury. BioMedSearch, 14. A A Sidi; J S Cameron; D D Dykstra; Y Reinberg; P H Lange, (2007)
- Media related to premature ejaculation at Wikimedia Commons